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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPR
All Species:
38.48
Human Site:
S252
Identified Species:
65.13
UniProt:
P35270
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35270
NP_003115.1
261
28048
S252
L
E
K
D
E
F
K
S
G
A
H
V
D
F
Y
Chimpanzee
Pan troglodytes
XP_525784
261
27897
S252
L
Q
K
D
E
F
K
S
G
A
H
V
D
F
Y
Rhesus Macaque
Macaca mulatta
XP_001103332
261
28016
S252
L
Q
K
D
E
F
K
S
G
A
H
V
D
F
Y
Dog
Lupus familis
XP_540234
267
28592
S258
L
Q
M
D
T
F
K
S
G
A
H
V
D
F
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q64105
261
27865
S253
L
Q
K
D
T
F
Q
S
G
A
H
V
D
F
Y
Rat
Rattus norvegicus
P18297
262
28110
S253
L
Q
R
D
T
F
Q
S
G
A
H
V
D
F
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520473
236
25629
R214
L
D
D
S
K
R
P
R
V
R
L
E
N
Q
I
Chicken
Gallus gallus
Q8JIS3
246
26149
S235
K
S
A
M
T
T
G
S
S
L
M
V
D
G
G
Frog
Xenopus laevis
Q7ZY31
263
28687
S255
L
E
A
D
A
Y
K
S
G
D
H
I
D
F
Y
Zebra Danio
Brachydanio rerio
NP_001019601
261
28523
S252
L
L
E
D
K
Y
S
S
G
E
H
L
D
Y
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624245
354
39811
S344
L
E
E
Q
K
Y
K
S
G
D
H
V
D
Y
Y
Nematode Worm
Caenorhab. elegans
Q21929
251
27201
S240
N
A
S
M
T
T
G
S
T
L
P
V
D
G
G
Sea Urchin
Strong. purpuratus
XP_783056
275
30198
S257
L
E
G
D
G
Y
E
S
G
A
H
V
D
Y
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40579
254
27462
N238
H
G
I
P
D
G
V
N
G
Q
Y
L
S
Y
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.5
96.9
80.9
N.A.
74.3
74.4
N.A.
46.3
26.4
55.5
52.4
N.A.
N.A.
25.4
26
39.6
Protein Similarity:
100
98
99.6
89.1
N.A.
86.5
88.1
N.A.
58.6
44.8
69.9
74.3
N.A.
N.A.
41.5
46.3
58.5
P-Site Identity:
100
93.3
93.3
80
N.A.
80
73.3
N.A.
6.6
20
66.6
46.6
N.A.
N.A.
60
20
60
P-Site Similarity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
26.6
20
80
80
N.A.
N.A.
86.6
20
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
48.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
15
0
8
0
0
0
0
50
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
65
8
0
0
0
0
15
0
0
86
0
0
% D
% Glu:
0
29
15
0
22
0
8
0
0
8
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
43
0
0
0
0
0
0
0
50
8
% F
% Gly:
0
8
8
0
8
8
15
0
79
0
0
0
0
15
15
% G
% His:
8
0
0
0
0
0
0
0
0
0
72
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
8
% I
% Lys:
8
0
29
0
22
0
43
0
0
0
0
0
0
0
0
% K
% Leu:
79
8
0
0
0
0
0
0
0
15
8
15
0
0
0
% L
% Met:
0
0
8
15
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
8
0
0
0
0
8
0
8
% N
% Pro:
0
0
0
8
0
0
8
0
0
0
8
0
0
0
0
% P
% Gln:
0
36
0
8
0
0
15
0
0
8
0
0
0
8
0
% Q
% Arg:
0
0
8
0
0
8
0
8
0
8
0
0
0
0
0
% R
% Ser:
0
8
8
8
0
0
8
86
8
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
36
15
0
0
8
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
8
0
0
72
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
29
0
0
0
0
8
0
0
29
65
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _